Trimethoprim is not a sulphonamides but it shows anti-bacterial activity by inhibiting the Folate Reductase in Para Amino Benzoic Acid (PABA) metabolism. Trimethoprim is closely related to antimalarials but it does not show any sufficient activity against malaria.
It is being widely used in combination with sulphonamides and this combination exhibits bactericidal effect in contrast to parents, which are individually bacteriostatic
STRUCTURE-ACTIVITY RELATIONSHIP
When one of the primary amines is removed, activity is completely lost.
The removal of one or more methoxy groups results in loss of activity up-to varying degree.
USES
Can be safely used alone in sulphonamide hypersensitive people to eradicate Gram-negative infections.
It is especially used in UTIs (Urinary Tract Infections) and prostatic infections.
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